Subject/Item | No. of items | Contents (Original version) | Validation | Target respondent | Changes by the Version (ver 1 and ver2) |
F/U Quest | |
---|---|---|---|---|---|---|---|
original | korean | ||||||
Zygosity screening | 5 | (Australian, Finnish, Swedish twin study) | + | + | Twin | No | |
Family members | 5 | Asking total family and biological relationship | Twin | V1 twins only -> V2 : All | No | ||
Birth and development, handedness of twin |
20 | (Australian, Finnish, Swedish twin study) | + | Twin | No | ||
Life time residence | 3 | Area of residence since birth (both twin) | Twin | No | |||
Perinatal history | 8 | (Australian, Finnish, Swedish twin study) | twin's mother | No | |||
Demographics | 6 | For 35 disease entities | All | No | |||
Past medical history | 35 | For 35 disease entities | All | V2 +retinal diseases, benign tumor of breasts |
Yes | ||
family history of disease and total family members | 6 | For 17 disease entities | All | V2 +thyroid diseases, retina/cataract/glaucoma | Yes | ||
Occupation & shift work | 4 | For 35 disease entities | All | V2 +regular or temporary position | Yes | ||
Job Stress | 25 | Karasek | + | + | All | V2 +difficulty-reward model f/u Q: difficulty-reward model only | Yes/No |
Depression Scale | 20 | All | |||||
Medication | 8 | NSAIDs and vitamins | All | V2 +Antibiotics & prescribed Rx during 6 Months | Yes | ||
smoking & ETS with FTND | 17 | + | + | All | Yes | ||
Alcohol intake with AUDIT | 14 | + | + | All | Yes | ||
Facial flushing | 2 | Do you flush with small amount of alcohol? | + | + | All | Only V2 and f/u Q | Yes |
socio-economic position | 4 | Categorical income level / household No. / education level / marital status | All | Yes | |||
Physical activity | 19 | IPAQ long form | + | + | All | Short form in f/u quest. -> | Yes |
lifetime weight change | 11 | Harvard | All | V2 +Antibiotics & prescribed Rx during 6 Months | No | ||
Sleeping and snoring | 2 | Total duration of sleeping / snoring | + | + | All | No | |
anxieity sensitivity | 36 | the expanded anxiety sensitivity index | + | + | All | No | |
State/trait anxiety level | 40 | state trait anxiety inventory | + | + | All | No | |
Presbyopia screening | 4 | Harvard | - | All | Only in V2 & f/u Q | Yes | |
Personality | 140 | temperament and character inventory (TCI) | + | + | All | No | |
Broiled and fried food | 9 | Preference&frequency of burnt/fried food | All | Yes | |||
food frequency table | 108 | Standardized food items with photographic amount exhibitions | + | All | Yes | ||
eating behavior inventory | 33 | All | Yes | ||||
female reproductive history | 20 | All Women | Yes | ||||
sexual activity | 10 | Women taking Pap | Yes | ||||
regularity and speed of eating meal | 3 | All | Yes | ||||
salt intake | 4 | All | Yes | ||||
history of fracture | 3 | All | Yes | ||||
history of bowel disease | 2 | All | Yes | ||||
history of pregnancy induced diabetes | 2 | All Women | Yes | ||||
history of back pain | 4 | All | Yes | ||||
regular medication | 1 | All | Yes | ||||
handedness | 2 | All | Yes |
The language used in this questionnaire is Korean (current Korean version, which is the version 2 of above table), and you can also download the english version
Clinical measurements | Electrocardiogram, pulmonaryfunction test, chest X-ray, body composition analysis (Impedance), body fat measurement (DEXA), bone density (DEXA, whole body only) |
---|---|
Physical Examination | Physical examination, bloodpressure, height, weight, sitting height, arm span, head circumference, waist circumference, hip circumference Blood pressure, vital signs and whole body physical exams |
Cancer Screening | 1. mammography AND cytology of cervix uteri (pap smear)
2. endoscopies: recommend national cancer screening programs over age 40 (with incentive) 3. PSA (over age 40) |
Blood Tests and others | Fasting plasma glucose, fastingplasma insulin,
total cholesterol, HDL cholesterol, LDL cholesterol (directmeasure), triglyceride, high sensitivity C reactive protein (hs-CRP), totalprotein, albumin, gamma-glutamyl transferase (GGT), aspartate aminotransferase (AST), alanine amino transferase (ALT), creatinine, calcium, uric acid, complete blood cell count (CBC) with differential count HbA1C (since mid 2006), Routine urinalysis (7 items) |
Biological Specimens (# of aliquots) |
DNA extract (>total 100g, -5g, 5g, others #3),
Buffy coat with RNA preparation (2) (fixed by RNAlater ®, 2005) immortalized B-Cell line (>106 cells each, #3 ?? about 90% success), serum (0.5ml, #3), plasma (0.5ml #2~3), packed red blood cell (1ml, #1) stool samples (3~5g, #1, starting from 2007) -> Commode stool kit (since 2009) 12-hour urine (conical tubes #4~5), cervical smear and DNA extracts (mainly for HPV) |
Age | Men | Women | Twin indivs |
Family | Total | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Twin | Family | Sum | Twin | Family | Sum | ||||||||
MZ | DZ | MZ+DZ | MZ | DZ | MZ+DZ | ||||||||
20~29 | 20 | - | 20 | 159 | 179 | 57 | 5 | 62 | 165 | 227 | 82 | 324 | 406 |
30~39 | 234 | 66 | 306 | 180 | 480 | 397 | 86 | 490 | 243 | 733 | 796 | 423 | 1219 |
40~49 | 100 | 18 | 118 | 144 | 260 | 187 | 40 | 227 | 233 | 460 | 345 | 377 | 714 |
50~59 | 46 | 24 | 73 | 159 | 229 | 53 | 10 | 64 | 267 | 331 | 137 | 426 | 557 |
60~69 | 2 | - | 2 | 198 | 199 | 2 | - | 2 | 231 | 233 | 4 | 429 | 430 |
over 70 | - | - | - | 61 | 58 | 2 | - | 2 | 73 | 75 | 2 | 134 | 133 |
total | 402 | 108 | 519 | 901 | 1420 | 698 | 141 | 847 | 1212 | 2059 | 1366 | 2113 | 3479 |
Age | Men | Women | Twin indivs |
Family | Total | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Twin | Family | Sum | Twin | Family | Sum | ||||||||
MZ | DZ | MZ+DZ | MZ | DZ | MZ+DZ | ||||||||
20~29 | 6 | - | 6 | 51 | 57 | 33 | 2 | 35 | 62 | 97 | 41 | 113 | 154 |
30~39 | 155 | 43 | 198 | 93 | 291 | 279 | 60 | 340 | 144 | 484 | 538 | 237 | 775 |
40~49 | 71 | 13 | 84 | 85 | 169 | 150 | 27 | 177 | 133 | 310 | 261 | 218 | 479 |
50~59 | 29 | 16 | 45 | 79 | 124 | 42 | 9 | 51 | 154 | 205 | 96 | 233 | 329 |
60~69 | 2 | - | 2 | 117 | 119 | 2 | - | 2 | 148 | 150 | 4 | 265 | 269 |
over 70 | - | - | - | 27 | 27 | 2 | - | 2 | 40 | 42 | 2 | 67 | 69 |
total | 263 | 72 | 335 | 452 | 787 | 508 | 96 | 607 | 681 | 1288 | 942 | 1133 | 2075 |
link to: 2010 FBAT/PBAT Family-Based Association Test Workshop (Click!)
(Lecture was given by the members of Complex Disease and Genome Epidemiology Branch, SNUPH)
This workshop was held as the first part of 3-part workshop, and mainly focused on phenometrics (estimating overall genetic influence of complex traits). The other parts will be "'mapping and identifying common and genetic variants" and "public health implication and evolutionary context".
- Participants: Seoul National University School of Public Health, Genome Research Center, CDC Korea, Seoul Samsung Hospital and Sungkyunkwan University School of Medicine, etc
- Workshop handout (in Korean and in English) can be downloaded here
Imputation method has become an essential tool for recent collaborative studies, which enables direct comparison between studies with different SNP marker platforms. Asian HapMap data with 1.39 million SNP markers (consisting of unrelated Han Chinese (CHB) and Japaneses (JPT), 85 persons each) has served as valuable reference for imputing Asian data. However, imputation results with subjects in other Asian populations such as Koreans sometimes had not been satisfactory mainly due to different linkage disequilibrium structure between Koreans and CHG+JPT. To improve the imputation results, we combined Korean HapMap data (http://www.khapmap.org) consisting of 90 unrelated Koreans, and existing Asian HapMap3 (release 2) after phasing K-HapMap data. following is the summary of the combining process (click for larger image)
© 2017 쌍둥이 가족 건강 연구회 | Seoul National University Graduate School of Public Health